Muse cells: Multilineage-differentiating stress-enduring stem

Dr. Ozone Clinic proudly introduces, for the first time in the UAE, an advanced regenerative medicine protocol developed in Japan and scientifically supported by MuseCell™ Innovations. This treatment combines three superior-quality cellular and biological components in a single intravenous session to promote deep body regeneration, enhance immunity, and improve neurological functions. What is Muse stem cells?

is a specialized therapeutic protocol administered intravenously. It works in harmony to target inflammation, aging, immune disorders, and neurological weakness in a way that traditional treatments cannot achieve.

Key Components & Their Scientific Benefits

MuseCells™ (100 Million)

  • Promote anti-aging and reduce inflammation
  • Stimulate tissue regeneration and repair
  • Support immune system balance
  • Reach damaged tissue areas naturally
  • Zero tumorigenicity or immune rejection (as per comparative research)

MuseExosomes™ (1 Trillion)

  • Enhance neuroregeneration and memory
  • Provide powerful anti-inflammatory signals
  • Improve focus, mental clarity, and brain function
  • Optimize intercellular communication for full-body renewal

Cord Blood Plasma (100 ml)

  • Rich in natural growth factors
  • Supports deep cellular rejuvenation
  • Enhances skin vitality and systemic energy
  • Scientifically positioned at the frontier of regenerative medicine

Muse cells Is More Than a Supplement, It’s a System Reset

Designed for individuals seeking real, science-backed regenerative solutions, whether for aging, chronic stress, or performance optimization.

Why are Muse Cells called “Smart Cells”?

Muse cells (Multilineage-differentiating Stress-Enduring cells) are considered unique and “smart” stem cells because they perform precise reparative functions within the body without the need for external intervention or direction. Their characteristics include:

Automatically recognizing damage sites and migrating to them

Once there is an injury or inflammation in the body, Muse cells detect the signals from those areas and automatically migrate to them without the need for direct injection at the damaged site.

Smartly transforming into the required cell type

When they reach the site of damage, they transform into the appropriate type of cells (neuronal, cardiac, skin, hepatic, etc.), enhancing the healing process precisely and naturally.

Safe and non-immunogenic

They do not cause immune rejection and do not require tissue matching, allowing them to be used from donors without immune-related issues.

Enduring biological stress

Unlike some other types of stem cells, Muse cells can survive and remain effective in environments within the body that are full of inflammation and oxidative stress.

Stabilizing and remaining alive in the body

Most importantly, after injection, Muse cells retain the ability to stabilize within the body and stay alive for extended periods. This means they are capable of:

  • Constantly monitoring the body
  • Intervening and repairing any future damage even after a period of time post-injection

This makes their effect continuous and long-lasting, like an intelligent internal repair system that activates when needed.

Preparation of Muse Cells (Multilineage-differentiating Stress-Enduring Cells) is done through precise and approved steps in specialized laboratories.

Steps for Preparing Muse Cells:

  • Sample collection (source of cells)
  • Muse cells are extracted from donated human tissues, such as:
  • Bone Marrow
  • Adipose Tissue
  • or Cord Blood

✅ All sources come from living donors or from the umbilical cord after birth, with legal consent and strict health monitoring.

  • Isolation of Multipotent Stem Cells (MSCs)
  • Mesenchymal Stem Cells (MSCs) are extracted, as they contain Muse cells.
  • Cellular Stress Induction
  • The cells are exposed to stress conditions (like lack of oxygen or glucose or exposure to UV rays) for a certain period.
  • This selectively triggers only Muse cells to survive, while other less resilient cells die.
  • Muse cells distinguish themselves by their ability to survive this stress. ● Purification of Muse Cells

Advanced techniques such as:

  • Flow Cytometry
  • Surface Markers (like SSEA-3)
  • Are used to isolate only pure Muse cells.
  • Cell Expansion and Growth
  • The cells are cultured in sterile conditions to proliferate and increase in number.
  • They are closely monitored to ensure quality, effectiveness, and biological properties. ● Preparation for Injection or Extraction ● Muse cells can be used directly:
  • As live cells for injection (Fresh Muse Cells)
  • Or extract exosomes from them (Muse-derived Exosomes) for cosmetic or therapeutic use.

Mechanism of Action of Muse Cells in the Body Step-by-Step:

Injection and Entry into the Circulatory System

Muse cells are administered via intravenous or local injection (depending on the case).

Muse cells can withstand the conditions of transport in the bloodstream due to their high resistance to oxidative and thermal stress, distinguishing them from other stem cells.

Smart Sensing of Damage Sites

Muse cells have receptors on their surface that detect chemical signals released by injured or inflamed tissues.

These signals include:

  • Inflammatory cytokines (IL-6, TNF-α)
  • Nitric oxide and free radicals
  • Signals from oxygen deficiency (Hypoxia-inducible factors)

⚠ This is known as the Homing property, meaning they automatically migrate to areas of damage without the need for external direction.

Engraftment at the Injury Site

  • After reaching the site of damage, Muse cells adhere to the damaged tissues.
  • They remain alive at the damage site (unlike other stem cells, which die quickly or spread randomly).
  • They do not form tumors or uncontrolled proliferation because they do not divide indefinitely.
  • Release of Reparative Signals (Paracrine Signaling)

Muse cells begin secreting growth and repair factors, such as:

  • VEGF (to stimulate blood vessels)
  • BDNF (to support nerves)
  • TGF-β (to regulate immunity)
  • IGF, EGF, HGF

These factors activate the body’s native cells, reduce inflammation, and stimulate repair of surrounding cells.

Differentiation into Specialized Cells

Muse cells can transform into:

  • Neuronal-like cells
  • Myocytes
  • Cardiomyocytes
  • Skin and hepatic cells, etc.

This transformation only occurs when needed and in the damage environment, which is a smart property that prevents random differentiation.

Long-term Survival and Activation of Future Regeneration

One of the most important features of Muse cells is that they are stored in the body and remain alive for weeks to months, acting as a biological reserve. If the body later experiences an injury or inflammation, they reactivate themselves and move toward the affected area. This distinguishes them from other treatments that require constant repetition.

Benefits Resulting from the Mechanism of Action of Muse Cells:

  • Self-guided navigation to the damage site accurately
  • Does not cause tumors as it does not proliferate uncontrollably. ● Stress-resistant, survives in harsh conditions like oxygen deprivation ● Immune support, reduces inflammation and modulates immunity. ● Effective regeneration, transforms into specialized cells when needed ● Repair memory, remains in the body for future repairs.

Practical Example:

  • In a patient with neurological damage (e.g., stroke):
  • Muse cells are injected and pass through the bloodstream.
  • They recognize signals from the damaged brain.
  • They adhere there and release neurotrophic factors.
  • They gradually transform into supporting neuronal cells.
  • They reduce inflammation and enhance natural neuronal regeneration.

What Do Patients Report?

  • Noticeable boost in physical and mental energy
  • Improved sleep quality and cognitive performance
  • Faster recovery from fatigue, stress, or immune-related issues
  • Visible revitalization after just one session What Makes Muse cells Unique?
  • No genetic modification or manipulation
  • No immunosuppressants required
  • High compatibility with the human body
  • Effectively delivered through intravenous infusion
  • Durable effects compared to traditional MSC therapy
  • Used in elite protocols for aging, fatigue, and immune regulation

Scientific Advantages Over Traditional MSC Therapy